BeautyBio R45 The Reversal 3-Phase Retinol Booster System.is a patented advanced three-phase system that helps reduce the appearance of fine lines and wrinkles. Use nightly for 45 days, twice yearly. Use Phase 1 for two weeks, Phase 2 for the following two weeks, and Phase 3 for the final two weeks. LTKbeauty LTKsalealert